Singh1, S. Binita Chanu1, Th. Bidyababy1, W. Radhapiyari Devi1, S. Brojendro Singh1, Kh. Nongalleima1, Lokendrajit.

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Singh1, S. Binita Chanu1, Th. Bidyababy1, W. Radhapiyari Devi1, S. Brojendro Singh1, Kh. Nongalleima1, Lokendrajit. N2, Swapana. N3 and L. Its extract and metabolites possess significant pharmacological and insecticidal properties.

The chemical constituent have shown efficacy in biological activities such as antitumor, antinociceptive, antimicrobial, enzyme inhibitory, larvicidal, amoebicidal, Epstein-Barr virus activation inhibitory, relaxant, antiallergic, aromotherapeutic, Bovine Serum Albumin Binding activities etc.

Keywords: Kaempferia galanga L. In , scientists from rhizomatous herbs, widely distributed throughout the Department of Plantation Crops and Spices, College tropics and sub-tropics particularly in Africa and of Horticulture, Vellanikkara Kerala, India released South East Asia Holltum, where grown two varieties of K. The genus Kaempferia, a native of India comprising more than 60 species, has distributed in tropics and sub-tropics of Asia and Africa Indrayan et al.

A few species are grown as ground cover in the tropics or under cover in cold areas. They need high humidity and do well in pots alongside warm growing orchids or in beds beneath green house staging.

Leaves are two of three, spreading flat on the ground, rotund-ovate or sub-orbicular, deltoid- acuminate, thin, green; flowers white, on a short scape, fugacious, fragrant opening successively; lip Figure 1. Flowers and leaves of K. Singh Email: Kishore. Its alcoholic maceration has also been applied as a liniment for rheumatism Keys, ; Lieu, Phytochemistry Number of publications on the phyotchemistry has to do with the essential oil and extracts from the rhizome and leaf of this plant.

The edible fresh leaves represent a potential food values. Rhizomes of K. It Ethnopharmacology exhibits the highest level of Potassium K. Rhizomes of 0. Anti-nutritional factors, such as this plant have been traditionally used as stomachic trypsin and chymotrypsin inhibitors and cyanide are and incense Jiangsu, and for relieving not detected in the study.

The tuberous determined as Asp The powder of tubers 2. A chemical affections Kirtikar and Basu, In Thailand, the study has been previously carried out and the rhizome of K. Phytochemical muscular swelling and rheumatism Sirirugasa, studies carried out with K. Other cons- diseases and seizures, respectively Pongboonrod and tituents include 3-carene, camphene, borneol, cineol, Mai, ; Thamaree and Tankeyoon, ; kaempferol, kaempferide, cinnamaldehyde, p-metho- Sighabutra, The most common indication for xycinnamic acid, ethyl cinnamate and ethyl p- its uses besides hypertension include rheumatism, methoxycinnamate.

The rhizomes afforded a new asthma, headaches, cough, toothaches and as a monoterpene ketone whose structure was elucidated poultice for applying to bruises and wounds Perry as 3-Carenone by spectroscopic means and and Metzger, The rhizome is also used to treat determined its melting point as oC Kiuchi et abdominal pain, and as embrocating and sudorific to al.

A total of 58 and 56 compounds have been treat swelling and muscular rheumatism Huang et al. In China, this plant is used as a remedy for Indrayan et al. Major component, ethyl-trans-p- Metzger, ; Huang et al. Along al.

Additionally, with constituents such as ethyl cinnamate, ethyl p- the rhizomes of the plant that contain essential oils methoxycinnamic acid was reported. NeBIO I www. Structures of some phytoactive compounds reported from K. Recent work on the rhizome of Kaempferia sp. Rhizome was to Hela cells Kosuge et al. Extract of rhizome analyzed for insecticidal constituents Pandji et al. The ethyl esters of cinnamate as well as of p- caterpillars.

Mixed with oil, the rhizomes are used as metho-xycinnamate were the major constituents in a cicatrizant Ghani, The rhizomes are the rhizomes of K. The stimulatory, expectorant, carminative, and diuretic. Roasted rhizomes Bioactivity are applied hot in rheumatism and for festering The biological activities of the plant are treated under tumours. Crude extracts of the rhizome of K. Bacillus sp. Crude extract Escherichia coli, Salmonella sp.

The ethanolic rhizome extract of K. The acetone extract and sub-acute toxicities in rats. The hexane fraction shows no activity whereas methanol and petroleum was tested for dermal irritation in rabbits. The ether extract of the plant exhibited significant ethanolic extract when tested by the Hippocratic activity.

Central Nervous System depression such as decrease Methanol extract of K. The observed anti- Antinociceptive activity is investigated in mice and proliferative activity of Kaempferol was consistent rats using acetic acid-induced writhing, formalin, hot with reports that Kaempferol inhibits cancer cell plate and tail-flick tests at test doses of 50, and growth in various cells Bestwick et al.

This study supports the use in Casagrande and Darbon, ; Knowles et al. The anti-proliferative screened for anti-tumor promoter activity using the activity of Kaempferol is consistent with reports that short term assay of inhibition of O-tetradecanoyl Kaempferol inhibits cancer cell growth in various phorbolacetate TPA -induced EBV early antigen cells Bestwick et al.

Ethanolic and ; Knowles et al. Kaempferol can help to water extracts is investigated for their anti-allergic fight cancer because it reduces the resistance of activities using a RBL-2H3 cell line Tewtrakul and cancer cells to anti-cancer drugs such as vinblastine Subhadhirasakul, in the treatment of urticaria and paclitaxel.

An 8-year study is found that three and allergy. Essential oil Ute et al. The vaso-relaxant active compound, ethyl cinnamate, is isolated as colourless volatile oil. Ethyl p- b Insecticidal activities and other biological methoxycinnamic acid is also isolated as white activities needles but does not exhibit any relaxant effect on the 1.

Insecticidal activities precontracted thoracic rat aorta Othman et al. Inhalation of hexane extract at the doses of 1. Significant larvicidal activity against Culex example, as a smooth muscle relaxant and vaso- quinquefasciatus is demonstrated which has LC50 relaxant Huang et al.

Othman et al. This oil is tested for their anti- Subsequently, larvicidal and repellent activities of K. The hexane fraction possesses 3. Metabolites larvicidal potency against C. However, the protection time of pure K. The bioactivities of the extracts are listed as follows Extract Part of the Plant Uses References Ethanol Whole plant Promotes NO production in human umbilical vein endothelial cells Wattanapitayakul et al. The distance between the tryptophan residues Choochotte et al.

Indian system of medicine, Chinese medicine and littoralis in relative to controls Nugroho et al. These taxa produce various types of In vitro evaluation of amoebicidal activity of K. Kaempferol obtained from this castellanii and A. Further studies of keratitis is done and found that this extract possessed other phytoactive compounds will possibly lead to an effective amoebicidal for three species of exploration of new methods for therapeutic and Acanthamoeba Chiu et al.

Details are shown industrial application. This will help mankind in short in Table 1. Other biological activities elucidation of new drug molecule is needed. This The binding of Kaempferol with bovine serum compilation of works is a good source of albumin BSA is investigated at three different ethnobotanical, chemical and pharmacological temperaturas - , and K, by the information and usefulness of K.

The secondary Authors are thankful to Department of Biotech- structure of the protein has been changed by the nology, Govt. Surjit Singh and Indrayan, A.

Mangi Singh for their co-operation. Rathi, A. Comparative chemical study of two varieties of attractive medicinal plant Kaempferia References galanga Linn. Production Radiator Bestwick, C. Kaempferol Jantan, I.

Inhibitory effect of heterogeneousresponse, dominated by cell cycle compounds from Zingiberaceae species on human alternations. Chemico- Biological Interactions — platelet aggregation. Phytomedicine Effects of Materia Medica. Shanghai Scientific and Technological structurally related flavonoids on cell cycle progression Publisher, Shanghai, Biochemical Taesotikul, T. Pharmacology —


Toxicity of crude rhizome extract of Kaempferia galanga L. (Proh Hom).

KGPs were extracted and purified, and their structural characteristics and antitumor activity were further investigated. The UV spectrum, high-performance gel permeation chromatography HPGPC , Fourier-transform infrared spectroscopy FTIR , and ion chromatography IC were employed to evaluate the structural characteristics, and H22 tumor-bearing mice model was established to demonstrate the antitumor activity. Physicochemical analysis and UV spectrum results showed that the proportions of total sugar, protein, and uronic acid in KGPs were This study provided a theoretical foundation for the practical application of KGPs in food and medical industries. Introduction Kaempferia galanga L.


Kaempferia galanga





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