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Received Nov 15; Accepted Jun This article has been cited by other articles in PMC. Abstract Background Despite the large number of published papers analyzing the prognostic role of Ki in NSCLC, it is still not considered an established factor for routine use in clinical practice. The present meta-analysis summarizes and analyses the associations between Ki expression and clinical outcome in NSCLC patients. Methods PubMed, Cochrane, and Embase databases were searched systematically using identical search strategies.

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Full size image The tumor was surgically removed with a right partial maxillectomy extendiney to homolateral soft mucosa and clear magins. Reconstruction was accomplished with a temporalis muscle flap. The patient has been followed up for 6 months without any evidence of recurrence or metastasis. Discussion Fanconi Anemia is a rare autosomal recessive disorder characterized by various congenital malformations, progressive bone marrow failure at a very young age and of solid tumors development.

Presence of mutations of in one of the different FA genes, FA can be divided into eight complementary groups A, B, C, D1, D2, E, F, G , with each group having in common the cellular hypersensitivity to cross-linking agent.

The severity is determined by specific complementation group and over all by the type of genetic mutation. Because of these phenotypic differences among complementation groups, FA is a heterogeneous disease. If impaired genetic factors cause an early appearance of the FA syndrome, the same factors may cause an early appearance of malignancies. Thus, there are two distinct groups of patients: 1 severe genetic disturbance with early FA symptoms and early malignancies; 2 mild disturbances with delayed FA symptoms and late malignancies [ 2 ].

Kaplan suggested that there are two defects determining the development of cancer in FA patients: defective chromosomal stability and immunodeficiency [ 12 ]. Patients that have endured bone marrow transplantation have a greater incidence of malignancies development.

In these patients, there are four additional factors including pretransplant total body irradiation, cyclophosphamide treatment, chronic graft versus host disease, and prolonged immunosuppressive treatment after transplantation [ 2 , 13 , 14 ].

The highest incidence of cancer development in FA patients is reported by Kuttler [ 11 ]. Jansisyanont reported that the commonest localizations of squamous cell carcinoma in FA patients in descending order are: tongue, anogenital region, pharynx, larynx, oral mucosa, mandible and skin [ 13 ].

He presented 17 cases. In 13 patients the cancer localization was intra-oral. In 9 cases of these 13, the tongue was involved. FA patients develop squamous cell carcinoma at significantly earlier age than the general population.

Kenedy and Hart reported an average age of 27 years in FA patients [ 17 ] and the average time between age of FA diagnosis and cancer development is The aim is the tumour resection oncologic radicality. The main preoperative problem in patients with FA is the associated bone marrow failure, requiring preoperative haematologic consultations. The possibility of blood and platelet transfusion before surgery must be considered.

We think that the first approach in FA patients is surgical resection of primary HNSCC with, if necessary, neck dissection and reconstruction. Generally, FA patients withstand surgical procedures very well. A further concern for the surgeon is the development of postoperative complications, including wound infections and haematoma. Although our patient did not develop postoperative complications, FA patients can have serious problems in adjuvant therapy due to increased susceptibility to mutagenic stimuli [ 2 , 11 , 13 ].

In FA patients, radiotherapy and chemotherapy follow different therapeutic principles. In FA patients the increased susceptibility to XRT and CTx can present problems to determine and to deliver a cancericidal dose without causing significant damage to normal tissue.

Thus, in these patients standard doses for adjuvant therapy are generally reduced. Furthermore, the use of conventional protocols, which include cross-linking agents, can cause severe systemic complications, including irreversible aplastic anaemia and catastrophic organ damage [ 15 , 18 ]. Because SCC in FA is difficult to treat once advanced, it is necessary to diagnose malignancies at early stage. We agree with the protocol proposed by Kutler [ 11 ]. He suggests a careful biannual screening of the oral cavity and oropharynx that should start between the ages of 15 and However, in patients with FA with histrory of leucoplakia or recurrent oral lesions, head and neck examinations are recommended every six or eight weeks.

Conclusion We report a unique localization of hard and soft squamous cell carcinoma in a FA patient. The atypical clinical manifestation rendered the diagnosis more difficult. We recommend a quarterly follow up of the oral-rhino-pharynx complex in FA patients and to consider as carcinomas, all oral lesions that last more than two weeks.

References 1. Google Scholar 2. Google Scholar 3. Ann Intern Med.

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Results The results showed that Standard methods and interpretation criteria need to be established. Peer Review reports Background Lung cancer is one of the leading causes of cancer-related deaths in the world. Given the low response rate, the identification of the patients who are most likely to derive clinical benefit from EGFR-targeted therapy is important [ 1 — 6 ].

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Full size image The tumor was surgically removed with a right partial maxillectomy extendiney to homolateral soft mucosa and clear magins. Reconstruction was accomplished with a temporalis muscle flap. The patient has been followed up for 6 months without any evidence of recurrence or metastasis. Discussion Fanconi Anemia is a rare autosomal recessive disorder characterized by various congenital malformations, progressive bone marrow failure at a very young age and of solid tumors development. Presence of mutations of in one of the different FA genes, FA can be divided into eight complementary groups A, B, C, D1, D2, E, F, G , with each group having in common the cellular hypersensitivity to cross-linking agent. The severity is determined by specific complementation group and over all by the type of genetic mutation.

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Anal Bioanal Chem. The development and application of advanced proteomics technology and new experimental models has created unique opportunities for translational studies. In this study, we investigated the ovarian cancer proteome of the chicken, an emerging experimental model of OVC that develops ovarian tumors spontaneously. Matched plasma, ovary, and oviduct tissue biospecimens derived from healthy, early-stage OVC, and late-stage OVC birds were quantitatively characterized by label-free proteomics. Collectively, these data provide the first evidence for involvement of OVOS2 in the pathogenesis of both chicken and human ovarian cancer.

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Bar-Sagi has published over peer-reviewed articles in leading scientific journals. His main research interests include the molecular mechanisms of mammalian cell-cycle control and responses to DNA damage, and the cancer-predisposing aberrations of these regulatory pathways. Jiri Bartek has a total of more than publications in peer reviewed journals about in Nature, Science and Cell , with over He is currently member of the editorial boards of 10 high-medium impact biomedical journals and has won a number of awards including: , Czech Medical Association Award, Elected EMBO member, A.

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